一、个人简介

        韩雪，太阳集团见好就收9728教师，博士研究生学历，讲师；

       2022年博士毕业于河北农业大学食品科技学院。

        邮箱：hanxue@hbu.edu.cn 

二、主讲课程和研究方向

主讲课程：卫生学、卫生毒理学实验

研究方向：功能营养成分对慢性病的干预

三、代表性论文

1. Xue Han, Bingyao Bai, Wen Zhao et al, Dietary supplementation with polysaccharides from Ziziphus Jujuba cv. Pozao intervene immune response via regulating peripheral immunity and intestinal barrier function in cyclophosphamide-induced mice, Food & Function 2020, 11, 5992–6006（Q1, IF: 4.171）

2. Xue Han, Wen Zhao, Qian Zhou, et al, Procyanidins from hawthorn (Crataegus pinnatifida) alleviate lipid metabolism disorder via inhibiting insulin resistance and oxidative stress, normalizing the gut microbiota structure and intestinal barrier, and further suppressing hepatic inflammation and lipid accumulation, Food & Function 2022, 13(14), 7901-7917（Q1, IF: 6.317） 

3. Xue Han, Qian Zhou, Wen Zhao, et al, In vitro digestion and fecal fermentation behaviors of polysaccharides from Ziziphus Jujuba cv. Pozao and its interaction with human gut microbiota, Food Research International 2022, doi: 10.1016/j.foodres.2022.112022 (Q1, IF: 7.425) 

4. Xue Han, Qian Zhou, Wen Zhao, et al, Procyanidin Extract from Hawthorn (Crataegus pinnatifida): In vitro Digestion and Caco-2 Cell Permeability, and the Interaction with Gut Microbiota through Omics Analysis, Food Research International 2023, doi: 10.1016/j.foodres.2022.112393 (Q1, IF: 7.425)

5. Xinlong Cheng, Xue Han, Wen Zhao, et al, Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota, Food Research International2023, 169, 112942 (共同一作，Q1, IF: 7.425)

6. Qian Zhou, Xue Han, Wen Zhao, et al, Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function, Phytomedicine 2018, 51, 171-180. (共同一作，Q1, IF: 4.18) 

7. 韩雪，周茜，牛佳卉，等. 蔷薇红景天低聚原花青素对动脉粥样硬化大鼠肝脏的保护作用[J]. 食品科学， 2019, 40(01): 190-195.（EI） 

8. Huifang Zhang, Qian Zhou, Xue Han, Ming Li, Jing Yuan, Ran Wei, Xiaofu Zhang , Mengying Wu, Wen Zhao, Nitrogen-doped carbon dots derived from awthorn for the rapid determination of chlortetracycline in pork samples, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021(255): 119736.（Q1, IF: 4.098） 

9. Kaixuan Zhou, Qian Zhou, Xue Han, Zhe Gao, Ruyan Peng, Xuan Lin, Xinlong Cheng, Wen Zhao, In vitro digestion and fecal fermentation of polysaccharides from hawthorn and its impacts on human gut microbiota, Processes 2022, 10, 1922. (Q2, IF: 3.352) 

10. 周茜，韩雪，韩晓梅，等. 响应面试验优化乌梅熊果酸提取工艺及其对大肠杆菌的抑制作用，食品科学, 2016, 37(8): 67-73.（EI） 

四、科研项目

1.  基于LPS诱导的 Caco-2单层细胞损伤模型研究山楂原花青素调节肠道胆固醇转运作用机制    河北省自然科学青年科学基金   4万    2023.01-2025.12   主持

2.  山楂原花青素通过调节胆汁酸代谢改善肠道屏障及胆固醇代谢的作用机制   太阳集团见好就收9728人才引进项目  10万 2023.06-2026.05   主持

3.  基于精准营养的山楂高值化利用关键技术研究   河北省重点研发项目  30万 2020.06-2023.06   参与

4.  河北特色营养食品研发与个性化营养干预研究   河北省引智项目  20万   参与